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1.2 Ghrelins integration into GH regulation The discovery of ghrelin as a potent GH secretagogue significantly advanced our understanding of GH regulation, previously viewed through the simplified GHRH-SST paradigm

Despite these positive signals, the clinical evidence remains limited by several key factors: small sample sizes, heterogeneity in probiotic strains, dosages, and administration routes, short follow-up periods, and a primary focus on BV and VVC rather than HPV clearance as the primary endpoint

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In ALS, lower levels of GSH were found in the motor cortex and the corticospinal tractus in patients compared to healthy controls 12,13,14,15